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Retinal Dopamine and Circadian Clocks: Roles in Eye Development, Function, and Dysfunction

By: P. Michael Iuvone, PhD, FARVO, Sylvia M. and Frank W. Ferst Professor of Ophthalmology, Co-Director of Vision Research, Departments of Ophthalmology & Pharmacology, Emory University School of Medicine

Retinal dopamine is secreted by a small subpopulation of amacrine and interplexiform cells. Despite this limited cellular localization,dopamine has multiple effects on ocular development and function due to its ability to communicate via volume transmission and theexpression of dopamine receptors on almost all retinal cell types, retinal pigment epithelia, and vasculature. Similarly, nearly all retinalcell types contain circadian clocks, many of which are entrained by dopamine, which regulate a variety of ocular functions. In this talk,I will discuss research into the roles of dopamine and circadian clocks in ocular vascular development, retinal circuitry development,visual function and adaptation, eye growth and myopia, and photoreceptor degeneration during aging.

Faculty Host: Tim Gawne, Ph.D

Refreshments provided. Please RSVP to Amy Drinkard by 5/13

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