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X-WR-CALNAME:DBIDS Summer Lecture Series:  Steve Horvath\, PhD
X-WR-TIMEZONE:Central Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20261015T233826Z
UID:tag:localist.com\,2008:EventInstance_53419884229239
DTSTART:20260722T170000Z
DTEND:20260722T180000Z
DESCRIPTION:Join us for an insightful presentation by Steve Horvath\, PhD\,
  Professor\, Division of Geriatrics\, David Geffen School of Medicine\, UC
 LA.  Director\, Aging Biology Research\, Department of Medicine.\n\nSchola
 r Profile\n\nTitle:  "Epigenetic Clocks: Statistical Foundations\, Emergin
 g Computational Challenges\, and What They Still Can't Tell Us"\n\nAbstrac
 t:  DNA methylation clocks have become the most widely used molecular esti
 mators of biological age\, and they are increasingly deployed as surrogate
  endpoints in geroscience trials. In this talk I will lay out how epigenet
 ic clocks are actually built (from penalized regression to deep learning o
 n high-dimensional methylation data)\, the choice of training outcome (chr
 onological age\, phenotypic age\, mortality risk\, pace of aging)\, and th
 e consequences those choices have for what a clock measures. I will then t
 urn to the problems that remain open: technical noise and low reliability 
 at the CpG level\, confounding by cell-type composition\, the fact that cl
 ocks are trained on cross-sectional data but interpreted longitudinally\, 
 and the persistent gap between predictive association and causal relevance
 . I will discuss recent work on causal versus non-causal CpGs\, single-cel
 l and cell-type-resolved clocks\, and what would be required for an epigen
 etic age measure to serve as a credible surrogate endpoint. The talk is ai
 med at a bioinformatics and clinical data science audience. I will be expl
 icit about where I think the methods are heading and where they currently 
 fall short.\n\nBiography:  Steve Horvath is Professor of Medicine in the D
 ivision of Geriatrics at the David Geffen School of Medicine\, UCLA\, and 
 Director of Aging Biology Research in the Department of Medicine. Trained 
 in mathematics and biostatistics\, he works at the interface of computatio
 nal biology and the biology of aging. He developed the epigenetic clock me
 thod for estimating biological age from DNA methylation data\, and subsequ
 ent biomarkers including second generation clocks such as GrimAge\, and th
 e mammalian methylation clocks\, which extend the approach across more tha
 n 300 species. He is a founder of the non-profit Epigenetic Clock Developm
 ent Foundation\, and was previously a Principal Investigator at Altos Labs
 .
LOCATION:
SUMMARY:DBIDS Summer Lecture Series:  Steve Horvath\, PhD
URL;VALUE=URI:https://calendar.uab.edu/event/dbids-summer-lecture-series-st
 eve-horvath-phd
CATEGORIES:Lectures & Presentations
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